Fig. 6. Up-regulation of DUSP6 after myocardial stretch. Five minutes of myocardial stretch ("St") promotes a significant increase in mRNA (A) and protein (B) expression of DUSP6, compared to non-stretched controls ("C"), effects that were precluded by the p38-MAPK inhibitor SB202190 ("St+SB"). In contrast, not significant changes in DUSP7 mRNA expression was found either in the absence or presence of SB202190 (C).* indicates p<0.05 vs. Control ("C"), # indicates p<0.05 vs. St.